When trying to find an answer to the question “Which is better Duromine or Reductil”, you need to take a closer look at the advantages and disadvantages of these meds. Before we do, keep in mind that these weight loss medications contain different active ingredients, which, though affecting the same nerve systems, do it in a different way and to a different extent. Check out the table below to see the differences of Duromine vs Reductil.

Name of the drug



Active ingredient



Possible dangerous side effects

Pulmonary hypertention

Tachycardia, Stroke

Treatment duration

Max. 3 months in a row


Weight loss

At least 5-10% of initial body weight in 12 weeks

1.8 kg in the first 4 weeks

Though the list of differences of these medications is a lot longer, the important thing to mention here is that Duromine (Phentermine) is a weight loss medication, which is approved by various health authorities of different countries, including the FDA and the TGA, while Reductil (Sibutramine) was banned for sale by the FDA, the TGA and the EMA because of high risk of cardiovascular side effects, discovered during Sibutramine trials.

Resources for reference: New Zealand Duromine *PDF | Consumer Medicine Information *PDF | Sibutramine hydrochloride monohydrate *PDF